Neutralization of TNF is a highly effective therapeutic intervention in many inflammatory diseases, such as rheumatoid arthritis, ankylosing spondylitis, psoriasis, Crohn's disease, and endotoxin‐induced septic shock (Beutler et al., 1985; Brandt et al., 2000; Chaudhari et al., 2001; Elliott et al., 1993, 1994; Hess et al., 2011; Knight et al., 1993; Lipsky et al., 2000; Lovell et al., 2000; Maini et al., 1998, 1999; Present et al., 1999; Stidham et al., 2014; van Dullemen et al., 1995). The gene discussed is TNF; the disease is rheumatoid arthritis.