TNF and early-onset autosomal dominant Alzheimer disease: Work with experimental animal models has shown that TNF neutralization is an effective therapeutic in heart disease and neurodegenerative diseases like Alzheimer's disease (Csiszar et al., 2007; Moe et al., 2004; Shamim & Laskowski, 2017; Toufektsian et al., 2008; Wolfe & Michaud, 2004).