demonstrated that in ischemic stroke, cGAS‐STING regulates IRF3 and NF‐κB to promote microglial polarization toward the M1 phenotype and inhibit microglial polarization of M2, thus causing neuroinflammation (TNF‐α, IL‐6, IL‐1β) and cognitive function. This evidence concerns the gene NFKB1 and ischemic stroke.