PTEN and neoplasm: Furthermore, GP73 knockout profoundly reduced the tumor number (HBV; Pten−/− vs HBV; Pten−/−; Gp73−/−: 11 ± 4.23 vs 4.87 ± 3.18) and size (HBV; Pten−/− vs HBV; Pten−/−; Gp73−/−: 10.54 ± 3.73 vs 4.98 ± 2.50) of HBV; Pten−/− mice (p < 0.01, Fig. 5C, D).