As detailed in the results, the obtained in vitro data confirmed, first, the capability of different taxanes (i.e. paclitaxel, docetaxel and carbazitaxel) to promote an autophagic response in TNBC cell lines and highlighted – at the same time – the capability of TRF2 to impair drug-induced autophagy, leading to a dramatic reduction of cancer cells proliferation. The gene discussed is TERF2; the disease is cancer.