TERF2 and breast cancer: To this aim, a well-established TNBC model, MDA-MB-231 cells, over-expressing (pBabe-TRF2) or not (pBabe-empty) TRF2 (Fig. S1a), underwent to treatment with Paclitaxel, Epirubicin and Carboplatin – three drugs representative of main classes of cytotoxic agents (taxanes, platins and anthracyclines) used for the treatment of BC – and the entity of autophagy was evaluated (Fig. 1).