While a significant positive correlation between EGFR and ARNTL2 is not evident, it is clear that the PI3K/AKT signaling pathway, a downstream component of EGFR signaling, is notably activated in pancreatic cancer (PC) cell lines exhibiting high ARNTL2 expression (Fig. 3G), suggesting an important role of ARNNTL2 in regulating EGFR signaling. Here, AKT1 is linked to pachyonychia congenita.