BMAL2 and pachyonychia congenita: While a significant positive correlation between EGFR and ARNTL2 is not evident, it is clear that the PI3K/AKT signaling pathway, a downstream component of EGFR signaling, is notably activated in pancreatic cancer (PC) cell lines exhibiting high ARNTL2 expression (Fig. 3G), suggesting an important role of ARNNTL2 in regulating EGFR signaling.