To determine if deletion of Tyrobp impacted levels of synaptic markers, as synaptic deficits may exist in neurodegenerative diseases [60, 61], we assayed synaptophysin and post-synaptic density 95 (PSD-95) protein levels and estimated the density of PSD-95 immunopositive puncta in striatum in the four groups of mice. This evidence concerns the gene DLG4 and neurodegenerative disease.