Typical pre-NFTs of Threonine 231 (p-tau T231) immunostaining identified neuropil threads staining in the FC and TC (arrowheads) and granular homogenous staining in the soma of transentorhinal (TETC), suggestive of pre-tangles in the T2DM monkeys (Fig. 4A). The gene discussed is MAPT; the disease is type 2 diabetes mellitus.