On the other hand, Bcl-2, Caspase-3, PARP, CDK2/4 and Cyclin D1 were upregulated while BAX, cleaved Caspase-3, cleaved PARP were downregulated in BPH-1 cells with NRK overexpression (Fig. 8B). The gene discussed is CASP3; the disease is benign prostatic hyperplasia.