KDM4A and acute myeloid leukemia: In addition, KDM4A enzymatic activity is known to be highly oxygen sensitive [42], which could imply that the KDM4A–NFATC2 axis has specific roles (or a lack thereof) to play across the variably hypoxic environments within the bone marrow microenvironment, at the site of AML residual disease; again, more sophisticated in vitro models should be used to assess this further.