Hence, several studies are seeking ways to circumvent the stability of XIST-mediated silencing of the normal MeCP2 allele to develop therapeutic strategies for Rett syndrome (Grimm and Lee 2022; Leko et al. 2018; Przanowski et al. 2018; Qian et al. 2023). The gene discussed is MECP2; the disease is atypical Rett syndrome.