PKHD1L1 and neoplasm: Furthermore, studies focused on uncovering the influence of mutations on the structure of the complete PKHD1L1 extracellular domain will help to better understand the role of PKHD1L1 in hearing function and beyond, since the PKHD1L1 has been suggested as a tumor suppressor (Yang et al. 2023) and a human cancer biomarker (Kafita et al. 2023; Wang et al. 2023; Zheng et al. 2019).