As compared with the MR analysis, more cardio-metabolic traits were identified to be correlated to the sepsis onset such as CRP (rg = 0.37, p = 0.035), type 2 diabetes (rg = 0.33, p < 0.001), HDL (rg = − 0.41, p < 0.001), coronary artery disease (rg = 0.43, p < 0.001), and BMI (rg = 0.55, p < 0.001). The gene discussed is CRP; the disease is Sepsis.