The causes of Cushing’s syndrome are usually classified into adrenocorticotropic hormone (ACTH)-dependent (e.g., Cushing’s disease, owing to an ACTH-secreting pituitary tumor) and ACTH-independent (e.g., a cortisol-secreting adrenal tumor) [15]. This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.