Notably, it has been shown that a high-fat diet (HFD) in mice with adipocyte-specific deletion of MR led to reductions in body weight, fat mass and hepatic steatosis compared to control mice [20•]; of note, decreased expression of genes associated with adipogenesis in the white adipose tissue of MR knock-out mice was also shown, thus implying that MR may mediate adipogenesis, hence affecting the liver [20•]. The gene discussed is NR3C2; the disease is fatty liver disease.