We reanalyzed a large MASLD cohort dataset (Govaere et al, 2020) (n = 216) to examine the expression levels of ER-reverted orthologs (45/49 genes) in MASLD patients separated by disease severity (CTRL, MASL, and MASH, collectively termed MASLD stages) (Fig. 5A and Table EV2). Here, CTRL is linked to metabolic dysfunction-associated steatotic liver disease.