INS and type 2 diabetes mellitus: We selected 67 genetic instruments for fasting glucose (R2: 4.7%, F statistics: 25 to 1662), 14 genetic instruments for 2-h glucose (R2: 1.3%, F statistics: 26 to 111), 74 genetic instruments for HbA1c (R2: 5.6%, F statistics: 25 to 1392), 38 genetic instruments for fasting insulin (R2: 1.4%, F statistics: 22 to 173), and 228 instruments for liability to type 2 diabetes (F statistics: 29 to 3136) (Supplementary Data 2).