Furthermore, AML blasts can also decrease NK cell cytotoxicity by releasing microvesicles containing TGFβ and IL-10 [98, 99] or by the secretion of cytokines such as TGFβ and IDO1, which also correlate with elevated Tregs number and suppression of T cell proliferation [100, 101] (Fig. 2C). This evidence concerns the gene IDO1 and acute myeloid leukemia.