Furthermore, RA, characterized by joint damage, hyperalgesia, and cachexia, has been responsive to the administration of orexin-A, evidenced by alleviated hyperalgesic symptoms and improved cachexia in an adjuvant-induced arthritis (AIA) rat model with daily intravenous orexin-A injections over an 8-day course63. The gene discussed is HCRT; the disease is Cachexia.