IL6 and kidney disorder: Remarkably, we show that HCMV-infected RPTECs—but not similarly infected HFFs or ARPE-19 cells—display a harmful secretory phenotype that induces IL-6-dependent paracrine senescence in neighboring uninfected epithelial cells, suggesting that HCMV-evoked senescence may specifically contribute to antiviral mechanisms and the pathogenesis of kidney disease.