It’s an autoimmune chronic degenerative disease that affects joints and extra-articular tissue50 Extracellular sulfatase-2 (Sulf-2) influences receptor–ligand binding and subsequent signaling by chemokines and growth factors, although its role in inflammatory cytokine signaling in Rheumatoid arthritis (RA) has not been explored51. This evidence concerns the gene SULF2 and rheumatoid arthritis.