The PCR-DNA sequence verdicts of healthy and affected buffaloes revealed differences in the SNPs in the amplified DNA bases related to endometritis for the A2M (304-bp), TLR2 (224-bp), TGF-β (420-bp), IRAK3 (310-bp), CCl2 (356-bp), FCAMR (330-bp), iNOS (445-bp), ADAMTS20 (369-bp), KCNT2 (420-bp), MAPK14 (300-bp), FKBP5 (345-bp), RXFP1(360-bp), EPHA4 (420-bp), SOD3 (360-bp), CAT (362-bp), GPX (287-bp), and NDUFS5 (328-bp) genes. Here, IRAK3 is linked to endometritis.