According to our knowledge, there has not been any prior research on the variation of the immune (A2M, TLR2, TGF-β, IRAK3, CCl2, and iNOS), metabolic (ADAMTS20, KCNT2, MAP3K4, MAPK14, RXFP1, FKBP5, RXFP1 FCAMR, and EPHA4), and antioxidant (SOD3, CAT, GPX, and NDUFS5) markers and how they relate to postparturient endometritis in buffaloes. Here, IRAK3 is linked to endometritis.