Then, in light of a recent important finding that AMPK deficiency increases caspase-6 activation in the liver in nonalcoholic steatohepatitis model mice41, we hypothesized that the suppression of AMPK activation might induce caspase-6 activation in the testis from AdipoR1 KO mice and investigated caspase-6 activity in the testis from AdipoR1 KO mice. The gene discussed is CASP6; the disease is metabolic dysfunction-associated steatohepatitis.