While lower connectivity amongst Tfh, T and B-cells was detected for SD (n = 8; CD4+ = 2, Th1/Th17/Th2 in CD4+ T-cells = 2, CD8+ = 2 and B-cells = 2), a higher number of correlations (n = 37; CD4+ = 6, Th1/Th17/Th2 in CD4+ T-cells = 6, CD8+ = 10 and B-cells = 15) was identified for FD vaccinees (Supplementary Figs. 5 and 6). The gene discussed is CD8A; the disease is Fabry disease.