For example, both MacroSig4 (DZ) and MacroSig6 (DLBCL) were negatively prognostic, and were associated with higher expression of M2-related markers such as CD209, CSF1R, IL10, and TGFβ-associated genes (TGFBI, TGFB1). This evidence concerns the gene IL10 and diffuse large B-cell lymphoma.