DSP and diffuse large B-cell lymphoma: Using DSP, through the application of a mask for CD68 (a broad marker for cells of macrophage-monocyte lineage)43,44, we defined macrophage transcriptomic signatures in reactive and malignant lymphoid tissue (termed MacroSig1-6; corresponding to biological/clinical categories listed in Table 1) and described their associations with known features of macrophage/DLBCL biology and clinical outcome (Fig. 7F).