As complement pattern recognition component genes (C1QA, C1QB, and C1QC) appeared as top ranking genes in the DZ signature (MacroSig4, Supplementary Data 2), and since C1Q expressing macrophages are a defined entity42, we evaluated the immunofluorescence staining of C1Q in RLTs and also in an additional independent set of DLBCL tissues in tissue microarray format from the Chi-Mei Medical Center (CMMC), Taiwan. This evidence concerns the gene C1QC and diffuse large B-cell lymphoma.