We also found that macrophage checkpoints such as SIRPα, LRLRB1, SIGLEC10, and PDCD1 are enriched in patients categorized to have MacroSig 6 (DLBCL) in comparison to MacroSig 5 (RLT) in eight DLBCL publicly available datasets (Supplementary Fig. 8). Here, PDCD1 is linked to diffuse large B-cell lymphoma.