PADI4 and Autoimmunity: We further analyzed the pad4-1 and bon1-1 bon2-2 bon3-3 pad4-1 mutants, as the autoimmunity-conferred lethality phenotype of the bon1-1 bon2-2 bon3-3 triple mutant is largely suppressed by the pad4-1 mutation (Fig. 3a, Supplementary Fig. 9a).