CIA09A amplifies both antibody and cell-mediated immune responses to various antigens, including recombinant TB antigens, inactivated Japanese encephalitis vaccine (JEV), and recombinant varicella-zoster virus (VZV) glycoprotein E (gE) antigen, while notably excelling in inducing a Th1-biased response characterized by IFN-γ cytokine production17–19. This evidence concerns the gene IFNG and tuberculosis.