Correspondingly, in RA patients, the proportion of memory CD4+ cells expressing ICOS correlated directly with the proportion of CD19+ B cells that were CD45+CD19+CD20-CD38highCD27+ plasmablasts (Pearson ρ = 0.58, P = 0.0026) (Fig. 4E). The gene discussed is CD19; the disease is rheumatoid arthritis.