We found an inverse correlation between hepatic ASGR1 mRNA expression and serum levels of liver function biomarkers, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), in patients with liver cirrhosis (Supplementary Fig. S2a–d). Here, GPT is linked to cirrhosis of liver.