CHEK2 and pure red-cell aplasia: Conflicting results as to whether pLOF CHEK2 mutations additionally predispose towards more aggressive disease had been reported previously [19,37], with our comparatively large single-population study supporting other more recent reports that did not find evidence for CHEK2 pLOF variants conferring a substantial contribution towards a greater likelihood of aggressive disease in men diagnosed with PrCa [21,36].