KLK3 and pure red-cell aplasia: A poorer prognosis of PrCa patients with increasing Gleason grade group has previously been established [32,33], although the optimal treatment approaches remain unclear for patients with intermediate-risk disease [34,35], commonly defined as prostate-confined tumours with grade group 2 (Gleason score 3 + 4) or grade group 3 (Gleason score 4 + 3) and PSA levels within a specified range.