In the primary analysis of aggressive PrCa classification, there were significant differences between aggressive and nonaggressive disease for ATM (OR = 2.67, 95% CI 1.56–4.56, p < 0.001), BRCA2 (OR = 5.13, 95% CI 2.98–8.83, p < 0.001), MSH2 (OR = 5.17, 95% CI 0.93–28.7), and NBN (OR = 18.9, 95% CI 1.12–320) mutation carriers (Supplementary Table 5). Here, MSH2 is linked to pure red-cell aplasia.