Furthermore, a recently identified new dystonia-associated gene, IMPDH2, supports the role of the purine metabolism in the dystonia pathogenesis.37 42 Based on the recent findings, the association between the purinergic pathways and the neurodevelopmental disorders has been proposed, however, the contribution of those mechanisms to the disease could not be yet elucidated. This evidence concerns the gene IMPDH2 and Dystonia.