CDC7 and Dystonia: Of those genes, MCM4 has been shown to be involved in DNA replication complex with a particular role in neurogenesis, and furthermore, CEN and PPI analysis showed that MCM4 and Cdc7 (online supplemental material S15a) might act as a complex in cell-cycle regulation, suggesting a possible role of the MCM4 gene in the cell-cycle-related dystonia pathogenesis (figure 2C).