Individual II:3 was also found to carry variant c.388G>A, p.(Glu130Lys) in crystallin beta 3 (CRYBB3; MIM*123630) (online supplemental figure 4), which is likely to explain the bilateral cataracts observed in him (MIM#609741).34 Variants that passed population and pathogenicity prediction filters but were not investigated further are detailed in online supplemental table 3 for each family. This evidence concerns the gene CRYBB3 and cataract.