To determine if cell phagocytosis is altered by inhibitor treatment in vivo, we treated Nf1fl/fl;DhhCre, β-actin-LSL-GFP tumor-bearing mice, in which GFP serves as a Schwann cell lineage marker with MEKi (PD0325901) alone, C5aRA (PMX205 or A8Δ71–73) alone, or the combination of MEKi and C5aRA for 60 d. Here, ACTB is linked to neoplasm.