C1QC and neoplasm: Bulk analysis of PNF macrophages revealed a mixed M1 (anti-tumor)/M2 (pro-tumorigenic) RNA signature, and single cell analysis revealed a subpopulation marked by CC1qa, C1qb, and C1qc, previously identified in tumor-promoting macrophages correlating with T-cell exhaustion (Choi et al, 2017; Kershner et al, 2022; Magrini et al, 2022).