We investigated all significant factors for correlation and performed multivariate Cox regression with the 10 selected candidate significant factors: anti-CCP levels, combined RF status and anti-CCP levels, number of HLA-SE alleles, ≥1 ACPA reactivity, ultrasound-detected tenosynovitis, IL-6, IL-17C, DNER, IL-15Rα and CXCL6 (Supplementary Tables S6 and S7, available at Rheumatology online). This evidence concerns the gene PRTN3 and tenosynovitis.