Then we analyzed the expression of hub genes across clinical stages (Fig. 6E), PPARG (P < .05), MMP2 (P < .05), and CXCR4 (P < .001), and the expression levels changed significantly with the advancement of pathological stages, indicating that the expression of the above genes causes obvious abnormal changes in cancer cells and tissues, and at the same time affects the tumor growth status and proliferation rate. This evidence concerns the gene MMP2 and cancer.