Five preoperative variables were independently associated with ER: CACI score ≥ 4 (OR 0.639, 95% CI: 0.440–0.929, P = .019), tumor size > 3.0 cm on the last preoperative CT scan (OR: 0.686, 95% CI: 0.485–0.970, P = .033), preoperative carcinoembryonic antigen (CEA) > 6.01 U/mL (OR: 0.644, 95% CI: 0.418–0.988, P = .047), clinical symptoms (OR: 0.451, 95% CI: 0.310–0.654, P < .001), and preoperative CA 19–9 level > 181.3 U/mL (OR: 0.428, 95% CI: 0.304–0.602, P < .001). The gene discussed is CEACAM5; the disease is neoplasm.