WFDC2 and neoplasm: The biochemical markers CA125 and HE4 achieved AUCs around 0.70 for the outcome of cytoreductive surgery.[15] A surgical score system by Kasper et al[16] and based on American Society of Anesthesiologists 3–4, tumor presence in multiple numbers and multiple compartments, and the number of involved organs achieved an AUC of 0.91 despite the fact that this score is based only on macroscopic lesions.