It is also known that insulin, a major regulatory hormone in Metabolic syndrome plays a role in increased circulation of WBCs.[80,81] In addition, increased resistance to insulin gives rise to higher serum viscosity, produces a prothrombotic state, and further increases pro-inflammatory cytokine release from the adipose tissue, all of which contributes to increased risk of cardiovascular diseases and T2DM. The gene discussed is INS; the disease is type 2 diabetes mellitus.