SERPINC1 and hereditary antithrombin deficiency: SERPINC1 mutation is an important factor leading to hereditary AT III deficiency, whose incidence in general population is 0.2‰ to 0.5‰, and in VTE patients is 1% to 8%.[12] Until April 2021, 486 SERPINC1 gene mutations have been registered in HGMD Professional Edition (https://www.hgmd.cf.ac.uk/ac/gene.php?gene=SERPINC1)mainly including missense mutations, nonsense mutations, splice site mutations, insertion, frameshift mutations, etc. More than 18% of these mutations are point mutations.