Mutations of FVL and prothrombin gene G20210A are more common in White Caucasians, while mutations in natural anticoagulants are more common in Asians.[7] According to the investigation and research on hereditary thrombophilia in China, the main cause of thrombophilia is anticoagulation protein defects, especially the mutations of SERPINC1, PROC, and PROS1. This evidence concerns the gene PROS1 and Rare hereditary thrombophilia.