F2 and thrombophilia: Mutations of FVL and prothrombin gene G20210A are more common in White Caucasians, while mutations in natural anticoagulants are more common in Asians.[7] According to the investigation and research on hereditary thrombophilia in China, the main cause of thrombophilia is anticoagulation protein defects, especially the mutations of SERPINC1, PROC, and PROS1.