The genomic landscape of lung cancer reveals extensive chromosomal rearrangements and a high mutational burden, such as the functional inactivation of the tumor suppressor gene TP53.[18] TP53, the most frequently mutated gene in lung cancer, leads to enhanced carcinogenic functions and is associated with shorter survival.[21] Our study revealed a positive correlation between high-KIFC1 expression and TP53 mutations, suggesting a potential link between these mutations and increased KIFC1 expression. The gene discussed is TP53; the disease is lung cancer.