Allo-SCT maintained lower CIR (p < 0.001) and superior OS (p = 0.008) than CMT for MRD<sup>high</sup> /CD19<sup>-</sup> patients.<h4>Conclusions</h4>MRD combined with CD19 might optimize PRT choices for adult t(8;21) AML patients in CR1. Here, CD19 is linked to acute myeloid leukemia.