Individual CpG sites differentially methylated in HCC case patients included genes encoding tumor suppressors (APC, RUNX3, RAR-β, PRDM2, SFRP1, RASSF1A, and RASSF5), regulators of cell cycle progression and death (DAPK1 and TP73), and DNA repair (MGMT, GSTP1, and MLH1) (Tables 4 and 5, Figure 2). This evidence concerns the gene SFRP1 and hepatocellular carcinoma.