NRSN2 and esophageal squamous cell carcinoma: We then searched for target genes that are clinically relevant as LUESCC (i.e., highly expressing in ESCC tumor tissues and positively correlated with poor prognosis of ESCC patients) using GEPIA and Oncolnc webtool (http://www.oncolnc.org/), which led to the discovery of one gene named NRSN2 (Fig. 3F–H and Table S5).