In addition, as mentioned above, the activation of NMDAR impairs FAO by reducing the phosphorylation and activity of PPARα through ELK1/2 pathway, and NMDAR is overactivated in high-fat diet-induced obese mice [64], suggesting that the FAO of obese patients may be further damaged during ALI, which in turn aggravates the lung injury. Here, ELK1 is linked to acute respiratory distress syndrome.