Interestingly, a selective overexpression of DGAT1 in mice macrophages and adipocytes exhibits a higher propensity for obesity, however, up-regulated DGAT1-dependent triacylglycerol storage ameliorates metabolic complications arising from obesity, including inflammatory macrophage activation, macrophage aggregation in white adipose tissue, systemic inflammation, and insulin resistance. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.