Interestingly, a selective overexpression of DGAT1 in mice macrophages and adipocytes exhibits a higher propensity for obesity, however, up-regulated DGAT1-dependent triacylglycerol storage ameliorates metabolic complications arising from obesity, including inflammatory macrophage activation, macrophage aggregation in white adipose tissue, systemic inflammation, and insulin resistance. This evidence concerns the gene DGAT1 and obesity disorder.