The regulation of multiple inflammatory mediators mediated by NF-κB is essential for the pathogenesis and progression of ALI inflammation, more importantly, CAV-1 plays an intermediary role in many signal pathways that lead to the activation of NF-κB, and the expression levels of CAV-1 and NF-κB are significantly up-regulated during ALI [46]. The gene discussed is CAV1; the disease is acute respiratory distress syndrome.