By establishing cecal ligation and puncture (CLP)-induced ALI murine model and lipopolysaccharide (LPS)-induced A549 cell model, Gong et al. [29] demonstrate that inhibition of FABP4 can effectively suppress ROS expression, thereby reducing the production of inflammatory cytokines such as C-X-C motif chemokine ligand 8 (CXCL-8), TNFα, IL-6, and IL-1β both in vivo and in vitro, providing a novel insight into the protective role of blocking FABP4 in LPS-induced ALI. Here, TNF is linked to acute respiratory distress syndrome.