In another study, Xu et al. [54] find that FFAR2 expression is significantly decreased in LPS-induced ALI mice and AECII cell models, while overexpression of FFAR2 can ameliorate LPS-induced lung injury and apoptosis through JNK/ELK1 signaling pathway, which further confirms the protective role of FFAR2 in ALI. Here, MAPK8 is linked to acute respiratory distress syndrome.