PIK3CA and cancer: This included pan-cancer across the entire cell line panel; per cancer type for the 14 most common cancer types in our panel (>19 cell lines); and 6 molecular “baskets” representing cancer type–agnostic cell line subpanels of the six most frequently mutated genes [TP53 (n = 477 cell lines), KRAS (n = 107), MLL2/KMT2D (n = 81), PTEN (n = 72), PIK3CA (n = 80), and BRAF (n = 61)].