CD247 and neoplasm: Thereafter, the fifth generation of CAR‐T cells was generated by inserting the interleukin‐2 receptor β‐chain [interleukin (IL)‐2Rβ] between the domains of CD3ζ and CD28 and adding the transcription factors STAT3 and STAT5 at the end of CD3ζ to improve the anti‐tumor efficacy of CAR‐T cells (Fig. 1B) [11].