To validate this in a larger dataset, we additionally analyzed 4 representative genes highly expressed in C8 cluster, including GBP1, GBP5, ANKRD22, and CD274, in the bulk RNA-Seq data from 18 patients with SLE and 32 HC as a proxy for C8 in all the participants. The gene discussed is GBP5; the disease is systemic lupus erythematosus.