HMGB1 and Schnyder corneal dystrophy: For example, the prothrombotic effects of HMGB1 are nullified in TLR4-deficient mice (17), and inhibition of signaling molecules within the myeloid differentiation factor 88–dependent (MyD88-dependent) pathway downstream of TLR4 in SCD platelets inhibits platelet inflammasome activity that is involved in platelet activation and thrombus formation (13, 17).