In poor response group, the age (P = 0.007), NIHSS score after rt-PA 24 h (P < 0.001), hypertension (P = 0.032), diabetes mellitus (P = 0.044), atrial fibrillation (P = 0.013), neutrophil count (P = 0.002), fibrinogen level (P < 0.001), NLR (P < 0.001), and PLR (P < 0.001) were significantly higher than those in good response group, while the lymphocyte count (P = 0.003) and Hb (P = 0.004) were significantly lower than those in good response group. Here, GSTM1 is linked to diabetes mellitus.