MTM1 and hemorrhagic stroke: Together with AgI/II, Cnm plays a crucial role in the aggravation of non-alcoholic steatohepatitis (NASH) (Naka et al., 2014, 2016, 2018); it is directly involved in and a potential risk factor for hemorrhagic stroke (Nakano et al., 2011) and IE (Nomura et al., 2013) and therefore can be considered as an indispensable virulence factor in the onset and progression of systemic diseases such as IE elicited by Cnm-positive S. mutans strains.