127 of the analyzed samples were high-grade bladder tumor tissues, with a majority of them showing HER2 protein expression in 115 cases (90.6%), 21 (16.5%) expressed HER2 1+, 79 (62.2%) expressed HER2 2+ and 16 (12.6%) expressed HER2 3+; Additionally, 36 cases were high-grade ureteral tumor tissues, and among them 25 cases (69.4%) expressed HER2 protein. Here, ERBB2 is linked to urinary bladder neoplasm.