ADCYAP1 and post-traumatic stress disorder: A sex-linked effect for higher levels of circulating peptide [pituitary adenylate cyclase-activating polypeptide (PACAP)], which binds to the pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1; PAC-1), was seen for the female symptoms/diagnosis of PTSD (34).